The Clinical Efficacy of Vitamin D Supplementation for Allergic Rhinitis
A Systematic Review and Meta-Analysis
DOI:
https://doi.org/10.70552/pjaai.24.1.9919Keywords:
Vitamin D, supplementation, adjunct, allergic rhinitisAbstract
Objective: To conduct a systematic review and meta-analysis of all controlled studies of vitamin D for treating allergic rhinitis to determine the efficacy of vitamin D supplementation to patients with allergic rhinitis.
Methodology: A systematic search was conducted using PubMed, Cochrane, CENTRAL databases, and Google Scholar for articles published in journals from 2010 to February 2023. The change from baseline in the Total Nasal Symptom Score (TNSS) was the main outcome. A random-effects model was used to pool the results of the included studies. Separate subgroup analyses were performed for studies using TNSS-12 and TNSS-15.
Results: Eight studies were included, including seven randomized controlled trials and one prospective analytical observational study. The combined sample size across all studies was 635 participants, including adults and children. Studies utilizing the TNSS-12 and TNSS-15 scales consistently demonstrated that the group receiving vitamin D supplementation had lower severity scores than the control group. The standardized mean difference (SMD) showed a statistically significant improvement in TNSS compared to the baseline, with an average SMD of 6.27 (95% CI, 3.96 to 8.59).
Conclusion: Vitamin D supplementation significantly improves nasal symptom scores of allergic rhinitis. It can be considered an adjunctive therapy in the management of allergic rhinitis. However, larger-scale studies are needed to confirm this conclusion.
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